An individual inherits LeLe Sese Hh AB. Which soluble antigens will be secreted in the patient's saliva?

• A. H, A, B, Le^a, Le^b
• B. H, A, B
• C. Le^a, Le^b
• D. H, Le^a, Le^b

Answer: (A)

This question tests how soluble blood group antigens appear in secretions based on secretor status and Lewis/H gene interactions. Because the person is Hh, there is H antigen available in secretions. Being AB means both A and B antigens can be produced as soluble ABH antigens in secretions if the secretor enzyme is present. The genotype LeLe indicates a Lewis-positive individual, and with secretor status (Sese), Leb is formed in secretions from Lea, so both Le^a and Le^b are present in saliva. Putting it together, the saliva would contain H, A, B, Le^a, and Le^b.