Anti-Le^a typically occurs in which phenotype?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the MT AAB Immunohematology Test with our engaging online quiz. Study with multiple-choice questions and detailed explanations. Boost your understanding and be exam-ready!

Multiple Choice

Anti-Le^a typically occurs in which phenotype?

Explanation:
Anti-Le^a antibodies are most commonly found in individuals who do not express the Le^a antigen on their red cells. That phenotype is Le(a-b-). If a person lacks Le^a, their immune system can recognize Le^a as foreign when exposed to Le^a on transfused cells or in other encounters, leading to antibody formation. In contrast, people who do express Le^a on their red cells are less likely to have anti-Le^a, because their immune system is not exposed to a foreign Le^a antigen. The Lewis system’s Le^a and Le^b expression depends on the FUT3 (Lewis) gene and, for Le^b, secretor status via FUT2; Le(a-b-) means neither antigen is present, making anti-Le^a most likely in this group.

Anti-Le^a antibodies are most commonly found in individuals who do not express the Le^a antigen on their red cells. That phenotype is Le(a-b-). If a person lacks Le^a, their immune system can recognize Le^a as foreign when exposed to Le^a on transfused cells or in other encounters, leading to antibody formation. In contrast, people who do express Le^a on their red cells are less likely to have anti-Le^a, because their immune system is not exposed to a foreign Le^a antigen. The Lewis system’s Le^a and Le^b expression depends on the FUT3 (Lewis) gene and, for Le^b, secretor status via FUT2; Le(a-b-) means neither antigen is present, making anti-Le^a most likely in this group.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy