Anti-N sometimes shows dosage effect. Which cells will it react with most strongly when showing this effect?

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Prepare for the MT AAB Immunohematology Test with our engaging online quiz. Study with multiple-choice questions and detailed explanations. Boost your understanding and be exam-ready!

Multiple Choice

Anti-N sometimes shows dosage effect. Which cells will it react with most strongly when showing this effect?

Explanation:
Antibody reactivity can depend on how much antigen is present on the cell surface—a concept called dosage. Anti-N binds best when there is a high density of the N antigen. Genotype-wise, NN cells carry two copies of the N antigen and thus have the highest density, Nn cells have an intermediate density, and nn cells lack the N antigen entirely. So anti-N will show the strongest reaction with NN cells, weaker with Nn, and no reaction with nn.

Antibody reactivity can depend on how much antigen is present on the cell surface—a concept called dosage. Anti-N binds best when there is a high density of the N antigen. Genotype-wise, NN cells carry two copies of the N antigen and thus have the highest density, Nn cells have an intermediate density, and nn cells lack the N antigen entirely. So anti-N will show the strongest reaction with NN cells, weaker with Nn, and no reaction with nn.

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