In Bombay phenotype, which antigen is absent on the red blood cell surface?

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Multiple Choice

In Bombay phenotype, which antigen is absent on the red blood cell surface?

Explanation:
H antigen is absent on the red blood cell surface in the Bombay phenotype. This condition results from a deficiency of the enzyme that adds fucose to create the H antigen—the precursor required for forming A and B antigens. Without H, neither A nor B antigens can be expressed, so these individuals type as O in standard ABO testing. A distinctive feature is the presence of anti-H antibodies in their serum, which react with H antigen on all normal donor cells that carry H. So the defining absent antigen on the red cell surface is H antigen.

H antigen is absent on the red blood cell surface in the Bombay phenotype. This condition results from a deficiency of the enzyme that adds fucose to create the H antigen—the precursor required for forming A and B antigens. Without H, neither A nor B antigens can be expressed, so these individuals type as O in standard ABO testing. A distinctive feature is the presence of anti-H antibodies in their serum, which react with H antigen on all normal donor cells that carry H. So the defining absent antigen on the red cell surface is H antigen.

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