In the indirect antiglobulin test, what is the role of IgG-sensitized red blood cells?

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Multiple Choice

In the indirect antiglobulin test, what is the role of IgG-sensitized red blood cells?

Explanation:
In the indirect antiglobulin test, the IgG-sensitized red blood cells serve as indicator cells. They are prepared so that red cells carry IgG on their surface. If the patient’s serum contains antibodies against the red cell antigens on these indicator cells, those antibodies bind during incubation, leaving the cells sensitized with IgG. When antihuman globulin (AHG) is added, it crosses the bound IgG on neighboring cells, causing agglutination. So the visible clumping of these sensitized cells reveals the presence of antibodies in the serum.

In the indirect antiglobulin test, the IgG-sensitized red blood cells serve as indicator cells. They are prepared so that red cells carry IgG on their surface. If the patient’s serum contains antibodies against the red cell antigens on these indicator cells, those antibodies bind during incubation, leaving the cells sensitized with IgG. When antihuman globulin (AHG) is added, it crosses the bound IgG on neighboring cells, causing agglutination. So the visible clumping of these sensitized cells reveals the presence of antibodies in the serum.

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