The preponderance of warm autoantibodies seems to be directed against which Rh antigen?

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Multiple Choice

The preponderance of warm autoantibodies seems to be directed against which Rh antigen?

Explanation:
Warm autoantibodies in autoimmune hemolytic anemia are typically IgG and often target Rh system antigens. Among the Rh antigens, the most frequently implicated target is the e antigen. This reflects the high prevalence of e on circulating red cells—almost everyone expresses e—so an autoantibody against e will bind to the majority of donor cells, producing broad reactivity. That’s why anti-e is the best-supported and most commonly observed specificity in warm autoantibodies.

Warm autoantibodies in autoimmune hemolytic anemia are typically IgG and often target Rh system antigens. Among the Rh antigens, the most frequently implicated target is the e antigen. This reflects the high prevalence of e on circulating red cells—almost everyone expresses e—so an autoantibody against e will bind to the majority of donor cells, producing broad reactivity. That’s why anti-e is the best-supported and most commonly observed specificity in warm autoantibodies.

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