What is the most common Rh negative genotype?

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Multiple Choice

What is the most common Rh negative genotype?

Explanation:
The presence of the D antigen is what determines Rh positivity. Rh negative individuals typically lack D because both chromosomes carry a D-negative background. The cde haplotype is the common D-negative RH background; having two copies of it means no D antigen is expressed on either chromosome. Therefore, cde/cde results in the Rh negative phenotype, making it the most frequent genotype for someone who is D-. The other possibilities involve at least one D-positive haplotype, which would produce a D antigen and thus a D+ phenotype.

The presence of the D antigen is what determines Rh positivity. Rh negative individuals typically lack D because both chromosomes carry a D-negative background. The cde haplotype is the common D-negative RH background; having two copies of it means no D antigen is expressed on either chromosome. Therefore, cde/cde results in the Rh negative phenotype, making it the most frequent genotype for someone who is D-. The other possibilities involve at least one D-positive haplotype, which would produce a D antigen and thus a D+ phenotype.

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