Which blood group is not typically associated with HDN?

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Multiple Choice

Which blood group is not typically associated with HDN?

Explanation:
Hemolytic disease of the newborn occurs when maternal IgG antibodies cross the placenta and attack fetal red cells that bear the corresponding antigen. Antibodies against Rh(D) and Kell as well as certain ABO antibodies are classic causes because they are typically IgG and can cross into the fetus to cause hemolysis. The Lewis system, by contrast, is different: anti-Lea or anti-Leb antibodies are usually IgM and do not cross the placenta effectively, and Lewis antigens are not robustly expressed on fetal red cells. Because of these factors, antibodies against Lewis antigens are not a typical cause of HDN.

Hemolytic disease of the newborn occurs when maternal IgG antibodies cross the placenta and attack fetal red cells that bear the corresponding antigen. Antibodies against Rh(D) and Kell as well as certain ABO antibodies are classic causes because they are typically IgG and can cross into the fetus to cause hemolysis. The Lewis system, by contrast, is different: anti-Lea or anti-Leb antibodies are usually IgM and do not cross the placenta effectively, and Lewis antigens are not robustly expressed on fetal red cells. Because of these factors, antibodies against Lewis antigens are not a typical cause of HDN.

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