Which Rh antigen is the most immunogenic?

Prepare for the MT AAB Immunohematology Test with our engaging online quiz. Study with multiple-choice questions and detailed explanations. Boost your understanding and be exam-ready!

Multiple Choice

Which Rh antigen is the most immunogenic?

Explanation:
D is the most immunogenic Rh antigen. When an Rh-negative person is exposed to D-positive red cells, the immune system is highly likely to mount a strong antibody response against D, making anti-D the most common and clinically significant alloantibody in the Rh system. This high immunogenicity is why Rh immune globulin is routinely given during pregnancy and after exposure to prevent anti-D formation. The other Rh antigens (C, E, and c) are less immunogenic, so antibodies to them form less readily than anti-D.

D is the most immunogenic Rh antigen. When an Rh-negative person is exposed to D-positive red cells, the immune system is highly likely to mount a strong antibody response against D, making anti-D the most common and clinically significant alloantibody in the Rh system. This high immunogenicity is why Rh immune globulin is routinely given during pregnancy and after exposure to prevent anti-D formation. The other Rh antigens (C, E, and c) are less immunogenic, so antibodies to them form less readily than anti-D.

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