Which statement about enzyme effects on Duffy antibodies is true?

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Multiple Choice

Which statement about enzyme effects on Duffy antibodies is true?

Explanation:
Enzymes digest or alter certain red cell surface proteins, and the Duffy antigens (Fy(a) and Fy(b)) are particularly sensitive to this proteolysis. When these antigens are destroyed by enzyme treatment, antibodies directed against them have nothing to bind to in the test, so their presence isn’t detected. That’s why enzyme-treated red cells can mask anti-Duffy antibodies, making detection fail. In practice, this means testing with untreated cells (or using methods that preserve antigen expression) is important when anti-Duffy antibodies are suspected.

Enzymes digest or alter certain red cell surface proteins, and the Duffy antigens (Fy(a) and Fy(b)) are particularly sensitive to this proteolysis. When these antigens are destroyed by enzyme treatment, antibodies directed against them have nothing to bind to in the test, so their presence isn’t detected. That’s why enzyme-treated red cells can mask anti-Duffy antibodies, making detection fail. In practice, this means testing with untreated cells (or using methods that preserve antigen expression) is important when anti-Duffy antibodies are suspected.

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