Which statement describes the purpose of titrating maternal anti-D antibodies?

• A. To quantify antibody level and guide RhIg dosing
• B. To determine fetal sex
• C. To assess maternal nutritional status
• D. To measure infant bilirubin

Answer: (A)

Measuring maternal anti-D antibody levels by titration is about quantifying how much anti-D antibody is circulating in the mother. This titer reflects whether the mother has become sensitized to the RhD antigen and how strong the immune response is. A low or absent titer suggests little or no sensitization, so standard Rh immune globulin prophylaxis can prevent alloimmunization and dosing decisions can be made for routine care after events that might expose the mother to Rh-positive blood. A rising or high titer indicates established sensitization and a higher risk of hemolytic disease in a future fetus, guiding closer fetal monitoring and management decisions. In that situation, RhIg is not used to treat an existing antibody response; instead, the focus shifts to monitoring and potential fetal interventions if needed. This titration is not about fetal sex, maternal nutrition, or newborn bilirubin measurement, which involve different tests and assessments.